Bupivacaine recalls
The FDA has published 24 recalls involving Bupivacaine since 2013. The latest was reported on 22 Apr 2026. Most were for particulate matter. Hospira has the most recalls in this group. Recalls usually affect specific lots, not every bottle on the market. Check the lot number on each recall page before acting.
Total recalls 24 since 2013
Last 12 months 1 reported
Class I 8 33% of total
Ongoing 2 latest 22 Apr 2026
Recalls per month, last 24 months click a bar for that month Severity split
8 33%15 63%1 4%
Why bupivacaine is recalled
Ongoing bupivacaine recalls 2 active
All bupivacaine recalls, newest first 24 total Reported Class Recall Company Reason Where 22 Apr 2026 Drug CLASS II Bupivacaine Hydrochloride 75% in 25% Dextrose Injection recalled Bupivacaine Hydrochloride Huons Co Sterility Nationwide 24 Aug 2022 Drug CLASS III Zynrelef (bupivacaine and meloxicam), 400 mg bupivacaine recalled Zynrelef Heron Therapeutics Packaging Defects Nationwide 15 Jun 2022 Drug CLASS II Bupivacaine HCl Injection, Single Dose Vial, 75%/7.5 mg/mL recalled Mckesson Medical-Surgical Inc. Corporate Office Manufacturing (CGMP) Deviations Nationwide 15 Jun 2022 Drug CLASS II Bupivacaine HCl Injection, single dose vial, Preservative Free recalled Bupivacaine Hydrochloride Mckesson Medical-Surgical Inc. Corporate Office Manufacturing (CGMP) Deviations Nationwide 15 Jun 2022 Drug CLASS II Bupivacaine HCl Injection, single dose vial, 5%/5 mg/mL recalled Mckesson Medical-Surgical Inc. Corporate Office Manufacturing (CGMP) Deviations Nationwide 15 Jun 2022 Drug CLASS II Bupivacaine HCl Injection, Multi dose vial, 25%/2.5 mg/mL recalled Mckesson Medical-Surgical Inc. Corporate Office Manufacturing (CGMP) Deviations Nationwide 15 Jun 2022 Drug CLASS II Bupivacaine HCl Injection, Multi dose vial, 50%/5 mg/mL recalled Mckesson Medical-Surgical Inc. Corporate Office Manufacturing (CGMP) Deviations Nationwide 15 Jun 2022 Drug CLASS II Bupivacaine Hydrochloride, USP 5% (5mg/mL), 25 vials x recalled Bupivacaine Hydrochloride Mckesson Medical-Surgical Inc. Corporate Office Manufacturing (CGMP) Deviations Nationwide 9 Jun 2021 Drug CLASS I 5% Bupivacaine Hydrochloride Injection, USP, 150 mg recalled by PFIZER Bupivacaine Hydrochloride PFIZER Packaging Defects Nationwide 11 Dec 2019 Drug CLASS II Exparel, Bupivicaine Liposome Injectable Suspension recalled Exparel Pacira Pharmaceuticals Sterility Nationwide
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Should you stop taking Bupivacaine?
Not on your own. Most recalls affect specific lots from one manufacturer, and stopping a prescription suddenly can be riskier than the defect. Check your lot number and NDC against the recall, then call the pharmacy that dispensed it for a replacement.